Choline and Betaine Intake and Colorectal Cancer Risk in Chinese Population: A Case-Control Study

Min-Shan Lu, Yu-Jing Fang, Zhi-Zhong Pan, Xiao Zhong, Mei-Chun Zheng, Yu-Ming Chen and Cai-Xia Zhang

PLOS ONE, 2015, vol. 10, issue 3, 1-14

Abstract: Background: Few studies have examined the association of choline and betaine intake with colorectal cancer risk, although they might play an important role in colorectal cancer development because of their role as methyl donors. The aim of this study was to examine the relationship between consumption of choline and betaine and colorectal cancer risk in a Chinese population. Methodology/Principal Findings: A case-control study was conducted between July 2010 and December 2013 in Guangzhou, China. Eight hundred and ninety consecutively recruited colorectal cancer cases were frequency matched to 890 controls by age (5-year interval) and sex. Dietary information was assessed with a validated food frequency questionnaire by face-to-face interviews. The logistic regression model was used to estimate multivariate odds ratios (ORs) and 95% confidence intervals (CIs). Total choline intake was inversely associated with colorectal cancer risk after adjustment for various lifestyle and dietary factors. The multivariate-adjusted OR was 0.54 (95%CI = 0.37-0.80, Ptrend

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0118661

DOI: 10.1371/journal.pone.0118661

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