Gender Differences in the Risk Factors for Endothelial Dysfunction in Chinese Hypertensive Patients: Homocysteine Is an Independent Risk Factor in Females

Cheng Cao, Jianxin Hu, Yifei Dong, Rui Zhan, Ping Li, Hai Su, Qiang Peng, Tao Wu, Liang Lei, Xiao Huang, Qinghua Wu and Xiaoshu Cheng

PLOS ONE, 2015, vol. 10, issue 2, 1-12

Abstract: Objectives: Endothelial dysfunction plays a key role in the pathogenesis of cardiovascular disease. However, the gender-related differences in risk factors for endothelial dysfunction are controversial. We investigated the gender differences in the risk factor profiles for endothelial dysfunction in Chinese hypertensive patients. Methods: Vascular endothelial functions in 213 hypertensive patients were measured by digital reactive hyperemia peripheral arterial tonometry (RH-PAT). Peripheral blood samples were collected, and the self-reported smoking and alcohol consumption status, age, body mass index, heart rate, blood pressure and drug administrations were recorded. Results: RH-PAT indexes were attenuated in both male and female hypertensive patients [1.60 (1.38-2.02) vs. 1.63 (1.44-1.98)]. Multivariate logistic regression analysis identified plasma creatinine (p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0118686

DOI: 10.1371/journal.pone.0118686

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