A Novel MiRNA-Based Predictive Model for Biochemical Failure Following Post-Prostatectomy Salvage Radiation Therapy

Erica Hlavin Bell, Simon Kirste, Jessica L Fleming, Petra Stegmaier, Vanessa Drendel, Xiaokui Mo, Stella Ling, Denise Fabian, Isabel Manring, Cordula A Jilg, Wolfgang Schultze-Seemann, Maureen McNulty, Debra L Zynger, Douglas Martin, Julia White, Martin Werner, Anca L Grosu and Arnab Chakravarti

PLOS ONE, 2015, vol. 10, issue 3, 1-19

Abstract: Purpose: To develop a microRNA (miRNA)-based predictive model for prostate cancer patients of 1) time to biochemical recurrence after radical prostatectomy and 2) biochemical recurrence after salvage radiation therapy following documented biochemical disease progression post-radical prostatectomy. Methods: Forty three patients who had undergone salvage radiation therapy following biochemical failure after radical prostatectomy with greater than 4 years of follow-up data were identified. Formalin-fixed, paraffin-embedded tissue blocks were collected for all patients and total RNA was isolated from 1mm cores enriched for tumor (>70%). Eight hundred miRNAs were analyzed simultaneously using the nCounter human miRNA v2 assay (NanoString Technologies; Seattle, WA). Univariate and multivariate Cox proportion hazards regression models as well as receiver operating characteristics were used to identify statistically significant miRNAs that were predictive of biochemical recurrence. Results: Eighty eight miRNAs were identified to be significantly (p 36 months). Nine miRNAs were identified to be significantly (p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0118745

DOI: 10.1371/journal.pone.0118745

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