Autophagic Signaling and Proteolytic Enzyme Activity in Cardiac and Skeletal Muscle of Spontaneously Hypertensive Rats following Chronic Aerobic Exercise

Elliott M McMillan, Marie-France Paré, Brittany L Baechler, Drew A Graham, James W E Rush and Joe Quadrilatero

PLOS ONE, 2015, vol. 10, issue 3, 1-21

Abstract: Hypertension is a cardiovascular disease associated with deleterious effects in skeletal and cardiac muscle. Autophagy is a degradative process essential to muscle health. Acute exercise can alter autophagic signaling. Therefore, we aimed to characterize the effects of chronic endurance exercise on autophagy in skeletal and cardiac muscle of normotensive and hypertensive rats. Male Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) were assigned to a sedentary condition or 6 weeks of treadmill running. White gastrocnemius (WG) of hypertensive rats had higher (p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0119382

DOI: 10.1371/journal.pone.0119382

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