Serum Resistin and Glomerular Filtration Rate in Patients with Type 2 Diabetes

Lorena Ortega Moreno, Lucia Salvemini, Christine Mendonca, Massimiliano Copetti, Concetta De Bonis, Salvatore De Cosmo, Alessandro Doria, Vincenzo Trischitta and Claudia Menzaghi

PLOS ONE, 2015, vol. 10, issue 3, 1-9

Abstract: Background: High serum levels of the pro-inflammatory adipokine resistin have been associated with decreased renal function in the general population. The goal of this study was to investigate whether such association is also present among diabetic subjects, who are at increased risk of renal function loss. Methods: The cross-sectional association between serum resistin levels and estimated glomerular filtration rate (eGFR) was investigated in 1,560 type 2 diabetic (T2D) patients of European ancestry comprised in two different cohorts: 762 patients from San Giovanni Rotondo (SGR; Italy) and 798 patients from Boston (US). Results: Serum resistin was inversely associated with eGFR in SGR [β (SE) for one SD of resistin increment = -1.01 (0.70) ml/min/1.73m2, p = 0.019] and in Boston [β (SE) = -5.31 (0.74) ml/min/1.73m2, p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0119529

DOI: 10.1371/journal.pone.0119529

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