Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A Systematic Review

Vikki G Nolan, Kerri A Nottage, Elliott W Cole, Jane S Hankins and James G Gurney

PLOS ONE, 2015, vol. 10, issue 3, 1-12

Abstract: Vitamin D deficiency has emerged as a public health focus in recent years and patients with sickle cell disease (SCD) reportedly have a high prevalence of the condition. Our objectives were to summarize definitions of vitamin D deficiency and insufficiency used in the literature, and to determine the prevalence and magnitude of each in patients with SCD through a systematic review conducted according to PRISMA guidelines. From a PubMed search, 34 potential articles were identified and 15 met eligibility criteria for inclusion. Definitions of deficiency and insufficiency varied greatly across studies making direct comparisons difficult. This review provides evidence to suggest that suboptimal vitamin D levels are highly prevalent among those with SCD, far more so than in comparable non-SCD patients or matched control populations. Defining deficiency as vitamin D

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0119908

DOI: 10.1371/journal.pone.0119908

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