Association between Resistin Levels and All-Cause and Cardiovascular Mortality: A New Study and a Systematic Review and Meta-Analysis

Andrea Fontana, Sara Spadaro, Massimiliano Copetti, Belinda Spoto, Lucia Salvemini, Patrizia Pizzini, Lucia Frittitta, Francesca Mallamaci, Fabio Pellegrini, Vincenzo Trischitta and Claudia Menzaghi

PLOS ONE, 2015, vol. 10, issue 3, 1-12

Abstract: Context: Studies concerning the association between circulating resistin and mortality risk have reported, so far, conflicting results. Objective: To investigate the association between resistin and both all-cause and cardiovascular (CV) mortality risk by 1) analyzing data from the Gargano Heart Study (GHS) prospective design (n=359 patients; 81 and 58 all-cause and CV deaths, respectively); 2) performing meta-analyses of all published studies addressing the above mentioned associations. Data Source and Study Selection: MEDLINE and Web of Science search of studies reporting hazard ratios (HR) of circulating resistin for all-cause or CV mortality. Data Extraction: Performed independently by two investigators, using a standardized data extraction sheet. Data Synthesis: In GHS, adjusted HRs per one standard deviation (SD) increment in resistin concentration were 1.28 (95% CI: 1.07-1.54) and 1.32 (95% CI: 1.06-1.64) for all-cause and CV mortality, respectively. The meta-analyses included 7 studies (n=4016; 961 events) for all-cause mortality and 6 studies (n=4,187: 412 events) for CV mortality. Pooled HRs per one SD increment in resistin levels were 1.21 (95% CI: 1.03-1.42, Q-test p for heterogeneity

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0120419

DOI: 10.1371/journal.pone.0120419

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