Serum Biomarkers in Patients with Relapsing Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss)

Christian Dejaco, Bastian Oppl, Paul Monach, David Cuthbertson, Simon Carette, Gary Hoffman, Nader Khalidi, Curry Koening, Carol Langford, Kathleen McKinnon-Maksimowicz, Philip Seo, Ulrich Specks, Steven Ytterberg, Peter A Merkel and Jochen Zwerina

PLOS ONE, 2015, vol. 10, issue 3, 1-8

Abstract: Introduction: Previous studies suggest a role for eotaxin-3, TARC/CCL17 and IgG4 in newly- diagnosed patients with eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss) with highly active disease. The role of these biomarkers in relapsing disease is unclear. Methods: Serum levels of TARC/CCL17, eotaxin-3, IgG4, and IgG4/IgG ratio were determined in serum samples from a longitudinal cohort of patients with EGPA (105 visits of 25 patients). Epidemiological, clinical and laboratory data were available for all visits. Results: At the first visit, 80% of patients were using glucocorticoids and 68% additional immunosuppressive drugs. Disease flares were seen at 18 visits. The median BVAS and BVAS/WG scores at time of relapse were 4 and 2, respectively. None of the biomarkers tested were useful to discriminate between active disease and remission. Patients treated with prednisone had lower eotaxin-3 and eosinophil levels compared to patients not taking glucocorticoids irrespective of disease activity. Use of immunosuppressive agents was not associated with biomarker levels. Conclusions: Serum levels of TARC/CCL17, eotaxin-3, IgG4, and IgG4/IgG ratio do not clearly differentiate active and inactive disease in established EGPA. Defining biomarkers in EGPA remains a challenge especially during times of glucocorticoid use.

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0121737

DOI: 10.1371/journal.pone.0121737

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