Primary Treatment Response Rather than Front Line Stem Cell Transplantation Is Crucial for Long Term Outcome of Peripheral T-Cell Lymphomas

Giuseppe Gritti, Cristina Boschini, Andrea Rossi, Federica Delaini, Anna Grassi, Alessandra Algarotti, Caterina Micò, Rosangela Trezzi, Andrea Gianatti, Anna Maria Barbui and Alessandro Rambaldi

PLOS ONE, 2015, vol. 10, issue 3, 1-11

Abstract: Outcome of systemic peripheral T-cell lymphomas (PTCL) is unsatisfactory and no controlled clinical study guides the therapy. Phase II studies suggest to consolidate response achieved after front-line treatment with stem cell transplant (SCT). We retrospectively evaluate the impact of front-line SCT consolidation in a single Center cohort of 209 patients treated during the last two decades. Median age was 49 years (range 15-85) with a prevalence of male sex (61%), advanced stage (68%) while IPI was >2 in 44%. Primary treatment was MACOP-B (39%) CHO(E)P (39%), intensive regimens (18%) or others (4%). Complete response to primary treatment (i.e. before SCT) was 60% (5% partial remission). Forty-four patients further proceeded to SCT while 92 did not receive consolidation. Outcome of primary responders was good, with a 3-year overall survival of 74% (82% in ALCL ALK+ and 69% for the other histologies). By multivariate analysis a better overall survival was significantly associated with IPI

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0121822

DOI: 10.1371/journal.pone.0121822

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