Prognostic Significance of Matrix Metalloproteinase-7 in Gastric Cancer Survival: A Meta-Analysis

Saeed Soleyman-Jahi, Saharnaz Nedjat, Afshin Abdirad, Niloofar Hoorshad, Reza Heidari and Kazem Zendehdel

PLOS ONE, 2015, vol. 10, issue 4, 1-17

Abstract: The prognostic role of matrix metalloproteinase-7 in gastric cancer survival has been widely evaluated. However, the results are controversial. We aimed to set up a meta-analysis to reach a conclusion on the prognostic significance of metalloproteinase-7 in gastric cancer survival as well as its association with clinicopathological parameters. We searched popular databases from 1988 until October 2014 to gather eligible peer-reviewed papers addressing the prognostic effect of matrix metalloproteinase-7 in gastric cancer patients' survival. The CASP check list was used for quality appraisal. Pooled hazard ratio (HR) for survival and odds ratio (OR) for association with their 95% confidence interval (CI) were considered as summary measurements. Finally, 1208 gastric cancer patients from nine studies were included in the meta-analysis. Pooled HR estimate for survival was 2.01 (95% CI = 1.62 – 2.50, P

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0122316

DOI: 10.1371/journal.pone.0122316

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