Helicobacter pylori Eradication on the Prevention of Metachronous Lesions after Endoscopic Resection of Gastric Neoplasm: A Meta-Analysis

Da Hyun Jung, Jie-Hyun Kim, Hyun Soo Chung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee and Yong Chan Lee

PLOS ONE, 2015, vol. 10, issue 4, 1-10

Abstract: Background: There is controversy about the effect of Helicobacter pylori (H. pylori) eradication on the prevention of metachronous gastric cancer after endoscopic resection (ER). Aims: The aim of this study was to systematically evaluate the effect of H. pylori eradication on the prevention of metachronous gastric lesions after ER of gastric neoplasms. Methods: We performed a systematic search of PubMed, EMBASE, the Cochrane Library, and MEDLINE that encompassed studies through April 2014. Our meta-analysis consisted of 10 studies, which included 5881 patients who underwent ER of gastric neoplasms. Results: When we compared the incidence of metachronous lesions between H. pylori-eradicated and non-eradicated groups, H. pylori eradication significantly lowered the risk of metachronous lesions after ER of gastric neoplasms (five studies, OR = 0.392, 95% CI 0.259 – 0.593, P

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0124725

DOI: 10.1371/journal.pone.0124725

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