A Weighted Polygenic Risk Score Using 14 Known Susceptibility Variants to Estimate Risk and Age Onset of Psoriasis in Han Chinese

Xianyong Yin, Hui Cheng, Yan Lin, Nathan E Wineinger, Fusheng Zhou, Yujun Sheng, Chao Yang, Pan Li, Feng Li, Changbing Shen, Sen Yang, Nicholas J Schork and Xuejun Zhang

PLOS ONE, 2015, vol. 10, issue 5, 1-11

Abstract: With numbers of common variants identified mainly through genome-wide association studies (GWASs), there is great interest in incorporating the findings into screening individuals at high risk of psoriasis. The purpose of this study is to establish genetic prediction models and evaluate its discriminatory ability in psoriasis in Han Chinese population. We built the genetic prediction models through weighted polygenic risk score (PRS) using 14 susceptibility variants in 8,819 samples. We found the risk of psoriasis among individuals in the top quartile of PRS was significantly larger than those in the lowest quartile of PRS (OR = 28.20, P

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0125369

DOI: 10.1371/journal.pone.0125369

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