The Association of Platelet Count with Clinicopathological Significance and Prognosis in Renal Cell Carcinoma: A Systematic Review and Meta-Analysis

Liangyou Gu, Hongzhao Li, Yu Gao, Xin Ma, Luyao Chen, Xintao Li, Yu Zhang, Yang Fan and Xu Zhang

PLOS ONE, 2015, vol. 10, issue 5, 1-12

Abstract: Objective: Elevated platelet count (PC), a measure of systemic inflammatory response, is inconsistently reported to be associated with poor prognosis in patients with renal cell carcinoma (RCC). We conducted a systematic review and meta-analysis to clarify the significance of PC in RCC prognosis. Methods: PubMed, Embase, and Web of Science databases were searched to identify eligible studies to evaluate the associations of PC with patient survival and clinicopathological features of RCC. Results: We analyzed 25 studies including 11,458 patients in the meta-analysis and categorized the included articles into three groups based on RCC stage. An elevated PC level was associated with poor overall survival (OS, hazard ratio [HR] 2.24, 95% confidence interval [CI] 1.87-2.67, P

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0125538

DOI: 10.1371/journal.pone.0125538

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