Effects of Age and Acute Ethanol on Glutamatergic Neurotransmission in the Medial Prefrontal Cortex of Freely Moving Rats Using Enzyme-Based Microelectrode Amperometry

Devesh Mishra, Nicholas R Harrison, Carolina B Gonzales, Björn Schilström and Åsa Konradsson-Geuken

PLOS ONE, 2015, vol. 10, issue 4, 1-15

Abstract: Ethanol abuse during adolescence may significantly alter development of the prefrontal cortex which continues to undergo structural remodeling into adulthood. Glutamatergic neurotransmission plays an important role during these brain maturation processes and is modulated by ethanol. In this study, we investigated glutamate dynamics in the medial prefrontal cortex of freely moving rats, using enzyme-based microelectrode amperometry. We analyzed the effects of an intraperitoneal ethanol injection (1 g/kg) on cortical glutamate levels in adolescent and adult rats. Notably, basal glutamate levels decreased with age and these levels were found to be significantly different between postnatal day (PND) 28-38 vs PND 44-55 (p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0125567

DOI: 10.1371/journal.pone.0125567

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