Association between CEBPE Variant and Childhood Acute Leukemia Risk: Evidence from a Meta-Analysis of 22 Studies

Jian Sun, Jinyu Zheng, Linjun Tang, Jasmine Healy, Daniel Sinnett and Yue-e Dai

PLOS ONE, 2015, vol. 10, issue 5, 1-11

Abstract: The CCAAT/enhancer binding proteins (CEBPs) have been involved in the etiology of acute leukemia (AL) and investigated in numerous genetic association studies, however, the results were inconclusive. The current meta-analysis was conducted to clarify the effect of CEBPE rs2239633 variant on childhood AL risk. Electronic literature search was performed on August 15, 2014, from databases of Medline, PubMed, Embase, and Web of Science. A total of 22 case-control studies were eligible for the pooled analysis. The results demonstrated that rs2239633 A allele was significantly associated with a decreased risk of childhood AL (A vs G: OR=0.87, 95%CI = 0.80, 0.94, p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0125657

DOI: 10.1371/journal.pone.0125657

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