Cross-Sectional and Prospective Associations between Physical Activity and C-Reactive Protein in Males

Aírton J Rombaldi, Lúcia C Pellanda, Renata M Bielemann, Denise P Gigante, Pedro C Hallal and Bernardo L Horta

PLOS ONE, 2015, vol. 10, issue 5, 1-10

Abstract: Background: There is conflicting evidence about the association between physical activity and inflammatory markers. Few prospective studies are available, particularly from low and middle-income countries. This study was aimed at assessing the cross-sectional and prospective associations between physical activity and C-reactive protein (CRP) levels in males belonging to the 1982 Pelotas (Brazil) Birth Cohort Study. Methods: The sample comprised 2,213 males followed up at the ages of 18 and 23 years. We performed high sensitivity CRP assays; we used a cut-off of 3 mg/L in categorical analyses. We measured physical activity by self-report at ages 18 and 23 years. Body mass index and waist circumference were studies as possible mediators. Results: CRP levels above the 3mg/L cut-off were found in 13.3% (95%CI: 11.7; 14.8) of the individuals. We found no evidence for an association between physical activity (leisure-time or all-domains) and either continuous (geometrical mean) or categorical CRP. We confirmed these null findings in (a) prospective and cross-sectional analyses; (b) trajectories analyses. Conclusions: There was no association between CRP levels and physical activity levels in early adulthood in a large birth cohort. Little variability in CRP at this early age is the likely explanation for these null findings.

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0125984

DOI: 10.1371/journal.pone.0125984

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