Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants versus Vitamin K Antagonist Oral Anticoagulants in Patients Undergoing Radiofrequency Catheter Ablation of Atrial Fibrillation: A Meta-Analysis

Giuseppe Santarpia, Salvatore De Rosa, Alberto Polimeni, Salvatore Giampà, Mariella Micieli, Antonio Curcio and Ciro Indolfi

PLOS ONE, 2015, vol. 10, issue 5, 1-18

Abstract: Background: Use of the non-vitamin K antagonist oral anticoagulants (NOACs) is endorsed by current guidelines for stroke prevention in patients with atrial fibrillation (AF). However efficacy and safety of NOACs in patients undergoing catheter ablation (RFCA) of AF has not been well established yet. Objectives: To perform a meta-analysis of all studies comparing NOACs and vitamin K antagonist oral anticoagulants (VKAs) in patients undergoing RFCA. Data Sources: Studies were searched for in PubMed and Google Scholar databases. Study Eligibility Criteria: Studies were considered eligible if: they evaluated the clinical impact of NOACs versus VKAs; they specifically analyzed the use of anticoagulants during periprocedural phase of RFCA; they reported clinical outcome data. Study Appraisal and Synthesis Methods: 25 studies were selected, including 9881 cases. The summary measure used was the risk ratio (RR) with 95% confidence interval (CI). The random-effects or the fixed effect model were used to synthesize results from the selected studies. Results: There was no significant difference in thromboembolic complications (RR 1.39; p=0.13). Bleeding complications were significantly lower in the NOACs-treated arm as compared to VKAs (RR=0.67, p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0126512

DOI: 10.1371/journal.pone.0126512

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