Livestock-Associated MRSA in Household Members of Pig Farmers: Transmission and Dynamics of Carriage, A Prospective Cohort Study

Brigitte A G L van Cleef, Birgit H B van Benthem, Erwin J M Verkade, Miranda M L van Rijen, Marjolein F Q Kluytmans- van den Bergh, Haitske Graveland, Thijs Bosch, Koen M H W Verstappen, Jaap A Wagenaar, Marian E H Bos, Dick Heederik and Jan A J W Kluytmans

PLOS ONE, 2015, vol. 10, issue 5, 1-13

Abstract: This prospective cohort study describes carriage of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) in household members from 49 farrowing pig farms in the Netherlands (2010–2011). Of 171 household members, 4% were persistent MRSA nasal carriers, and the MRSA prevalence on any given sampling moment was 10% (range 7-11%). Working in the stables (of which 98% was MRSA-positive, prevalence ratio (PR) = 2.11 per 10 hours), working with sows (PR=1.97), and living with an MRSA-positive pig farmer (PR=4.63) were significant determinants for MRSA carriage. Significant protective factors were carriage of methicillin-susceptible Staphylococcus aureus (MSSA) (PR=0.50), and wearing a facemask when working in the stables (37% decreased prevalence). All MRSA strains during the study period were known livestock-associated types. The bacteriophage φ3 was not found in household members. Transmission from pigs and the environment appeared to be important determinants; human-to-human transmission could not sufficiently be differentiated. Wearing a facemask when working in the stables and carriage of MSSA are potential interventional targets.

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0127190

DOI: 10.1371/journal.pone.0127190

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