Opioids Contribute to Fracture Risk: A Meta-Analysis of 8 Cohort Studies

Zhaowei Teng, Yun Zhu, Feihu Wu, Yanhong Zhu, Xiguang Zhang, Chuanlin Zhang, Shuangneng Wang and Lei Zhang

PLOS ONE, 2015, vol. 10, issue 6, 1-13

Abstract: Objective: To evaluate the association between chronic opioid use for non-cancer pain and fracture risk by conducting a meta-analysis of cohort studies. Methods: Cohort studies were identified by searching PubMed and EMBASE from their inception to July 2014. A fracture was considered an endpoint. The information was extracted by two authors independently. When the heterogeneity was significant, a random-effects model was used to calculate the overall pooled risk estimates. Results: Eight cohort studies were included in the final meta-analysis. On the basis of the Newcastle-Ottawa Scale (NOS), six studies were considered to be of high quality. The overall combined relative risk for the use of opioids and fractures was 1.88 (95% confidence interval [CI] 1.51-2.34). A subgroup analysis revealed the sources of heterogeneity. The sensitivity analysis indicated stable results, and no publication bias was observed. Conclusions: This meta-analysis of cohort studies demonstrates that opioids significantly increase the risk of fractures.

Date: 2015
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128232 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 28232&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0128232

DOI: 10.1371/journal.pone.0128232

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().