Effect of Dexmedetomidine on Preventing Postoperative Agitation in Children: A Meta-Analysis

Juan Ni, Jiafu Wei, Yusheng Yao, Xiaoqin Jiang, Linli Luo and Dong Luo

PLOS ONE, 2015, vol. 10, issue 5, 1-13

Abstract: Background: Emergence agitation (EA) is one of the most common postoperative complications in children. The purpose of this meta-analysis is to assess the effect of dexmedetomidine for preventing postoperative agitation in children. Methods: We searched the Cochrane Central Register of Controlled Trails, MEDLINE, and EMBASE. Randomized controlled trials were included. The following outcome measures were evaluated: incidence of EA, number of patients requiring rescue, time to eye-open, time to extubation, time to discharge from the postanesthesia care unit (PACU). Results: We analyzed 19 trials (1608 patients) that met the inclusion criteria. Compared with placebo, intravenous dexmedetomidine significantly reduced the incidence of EA [risk ratio (RR) 0.34, 95% confidence interval (CI) 0.25–0.44, P

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0128450

DOI: 10.1371/journal.pone.0128450

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