Dialyzer Reuse and Outcomes of High Flux Dialysis

Christos Argyropoulos, Maria-Eleni Roumelioti, Abdus Sattar, John A Kellum, Lisa Weissfeld and Mark L Unruh

PLOS ONE, 2015, vol. 10, issue 6, 1-23

Abstract: Background: The bulk of randomized trial evidence for the expanding use of High Flux (HF) hemodialysis worldwide comes from two randomized controlled trials, one of which (HEMODIALYSIS, HEMO) allowed, while the other (Membrane Outcomes Permeability, MPO) excluded, the reuse of membranes. It is not known whether dialyzer reuse has a differential impact on outcomes with HF vs low flyx (LF) dialyzers. Methods: Proportional Hazards Models and Joint Models for longitudinal measures and survival outcomes were used in HEMO to analyze the relationship between β2-microglobulin (β2M) concentration, flux, and reuse. Meta-analysis and regression techniques were used to synthesize the evidence for HF dialysis from HEMO and MPO. Findings: In HEMO, minimally reused (

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0129575

DOI: 10.1371/journal.pone.0129575

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