Perioperative Blood Transfusion Promotes Worse Outcomes of Bladder Cancer after Radical Cystectomy: A Systematic Review and Meta-Analysis

You-Lin Wang, Bo Jiang, Fu-Fen Yin, Hao-Qing Shi, Xiao-Dong Xu, Shuai-Shuai Zheng, Shuai Wu and Si-Chuan Hou

PLOS ONE, 2015, vol. 10, issue 6, 1-11

Abstract: Background: Multiple studies have investigated the effect of perioperative blood transfusion (PBT) for patients with radical cystectomy (RC), but the results have been inconsistent. We conducted a systematic review and meta-analysis to investigate the relationship between PBT and the clinical outcomes of RC patients. Methods: We searched MEDLINE, EMBASE, the Cochrane library and BIOSIS previews to identify relevant literature for studies that focused on the relationship of PBT and outcomes of patients undergoing RC. A fixed or random effects model was used in this meta-analysis to calculate the pooled hazard ratio (HR) with 95% confidence intervals (CIs). Results: A total of 7080 patients in 6 studies matched the selection criteria. Aggregation of the data suggested that PBT in patients who underwent RC correlated with increased all-cause mortality, cancer-specific mortality and cancer recurrence. The combined HRs were 1.19 (n = 6 studies, 95% CI: 1.11–1.27, Z = 4.71, P

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0130122

DOI: 10.1371/journal.pone.0130122

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