Analysis of Prostate Deformation during a Course of Radiation Therapy for Prostate Cancer

Takuya Nakazawa, Kunihiko Tateoka, Yuichi Saito, Tadanori Abe, Masaki Yano, Yuji Yaegashi, Hirokazu Narimatsu, Kazunori Fujimoto, Akihiro Nakata, Kensei Nakata, Masanori Someya, Masakazu Hori, Masato Hareyama and Koichi Sakata

PLOS ONE, 2015, vol. 10, issue 6, 1-9

Abstract: Purpose: Accurate analysis of the correlation between deformation of the prostate and displacement of its center of gravity (CoG) is important for efficient radiation therapy for prostate cancer. In this study, we addressed this problem by introducing a new analysis approach. Method: A planning computed tomography (CT) scan and 7 repeat cone-beam CT scans during the course of treatment were obtained for 19 prostate cancer patients who underwent three-dimensional conformal radiation therapy. A single observer contoured the prostate gland only. To evaluate the local deformation of the prostate, it was divided into 12 manually defined segments. Prostate deformation was calculated using in-house developed software. The correlation between the displacement of the CoG and the local deformation of the prostate was evaluated using multiple regression analysis. Results: The mean value and standard deviation (SD) of the prostate deformation were 0.6 mm and 1.7 mm, respectively. For the majority of the patients, the local SD of the deformation was slightly lager in the superior and inferior segments. Multiple regression analysis revealed that the anterior-posterior displacement of the CoG of the prostate had a highly significant correlation with the deformations in the middle-anterior (p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0131822

DOI: 10.1371/journal.pone.0131822

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