Two Adhesive Sites Can Enhance the Knotting Probability of DNA

Saeed Najafi and Raffaello Potestio

PLOS ONE, 2015, vol. 10, issue 7, 1-13

Abstract: Self-entanglement, or knotting, is entropically favored in long polymers. Relatively short polymers such as proteins can knot as well, but in this case the entanglement is mainly driven by fine-tuned, sequence-specific interactions. The relation between the sequence of a long polymer and its topological state is here investigated by means of a coarse-grained model of DNA. We demonstrate that the introduction of two adhesive regions along the sequence of a self-avoiding chain substantially increases the probability of forming a knot.

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0132132

DOI: 10.1371/journal.pone.0132132

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