Effects of Statins on Renal Outcome in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis

Anawin Sanguankeo, Sikarin Upala, Wisit Cheungpasitporn, Patompong Ungprasert and Eric L Knight

PLOS ONE, 2015, vol. 10, issue 7, 1-13

Abstract: Background: HMG CoA reductase inhibitors (statins) are known to prevent cardiovascular disease and improve lipid profiles. However, the effects of statins on renal outcomes, including decline in estimated glomerular filtration rate (eGFR) and proteinuria in patients with chronic kidney disease (CKD), are controversial. This meta-analysis evaluated the impact of statins on renal outcomes in patients with CKD. Materials and Methods: We comprehensively searched the databases of MEDLINE, EMBASE, and Cochrane Databases. The inclusion criteria were published RCT and cohort studies comparing statin therapy to placebo or active controls in patients with CKD (eGFR

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0132970

DOI: 10.1371/journal.pone.0132970

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