Variations in the FRA10AC1 Fragile Site and 15q21 Are Associated with Cerebrospinal Fluid Aβ1-42 Level

Qingqin S Li, Antonio R Parrado, Mahesh N Samtani, Vaibhav A Narayan and Alzheimer’s Disease Neuroimaging Initiative

PLOS ONE, 2015, vol. 10, issue 8, 1-17

Abstract: Proteolytic fragments of amyloid and post-translational modification of tau species in Cerebrospinal fluid (CSF) as well as cerebral amyloid deposition are important biomarkers for Alzheimer’s Disease. We conducted genome-wide association study to identify genetic factors influencing CSF biomarker level, cerebral amyloid deposition, and disease progression. The genome-wide association study was performed via a meta-analysis of two non-overlapping discovery sample sets to identify genetic variants other than APOE ε4 predictive of the CSF biomarker level (Aβ1–42, t-Tau, p-Tau181P, t-Tau:Aβ1–42 ratio, and p-Tau181P:Aβ1–42 ratio) in patients enrolled in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) study. Loci passing a genome-wide significance threshold of P

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0134000

DOI: 10.1371/journal.pone.0134000

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