Hypoxaemia as a Mortality Risk Factor in Acute Lower Respiratory Infections in Children in Low and Middle-Income Countries: Systematic Review and Meta-Analysis

Marzia Lazzerini, Michela Sonego and Maria Chiara Pellegrin

PLOS ONE, 2015, vol. 10, issue 9, 1-17

Abstract: Objective: To evaluate the association between hypoxaemia and mortality from acute lower respiratory infections (ALRI) in children in low- and middle-income countries (LMIC). Design: Systematic review and meta-analysis. Study Selection: Observational studies reporting on the association between hypoxaemia and death from ALRI in children below five years in LMIC. Data Sources: Medline, Embase, Global Health Library, Lilacs, and Web of Science to February 2015. Risk of Bias Assessment: Quality In Prognosis Studies tool with minor adaptations to assess the risk of bias; funnel plots and Egger’s test to evaluate publication bias. Results: Out of 11,627 papers retrieved, 18 studies from 13 countries on 20,224 children met the inclusion criteria. Twelve (66.6%) studies had either low or moderate risk of bias. Hypoxaemia defined as oxygen saturation rate (SpO2)

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0136166

DOI: 10.1371/journal.pone.0136166

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