Effect of Grape Polyphenols on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials

Shao-Hua Li, Peng Zhao, Hong-Bo Tian, Liang-Hua Chen and Lian-Qun Cui

PLOS ONE, 2015, vol. 10, issue 9, 1-12

Abstract: Background: The effect of grape polyphenols on blood pressure remains unclear, which we aimed to address via a meta-analysis study. Methods: We conducted study trial searches in PubMed, Embase, and the Cochrane Library databases. Summary estimates of weighted mean differences and 95% confidence intervals were obtained by using fixed-effects models. Subgroup analyses were performed to identify the source of heterogeneity. The protocol details of our meta-analysis have been submitted to the international database of prospectively registered systematic reviews (registration number CRD42015019196). Results: Ten studies were included in the present meta-analysis. Our results showed daily grape polyphenol intake could significantly reduce systolic blood pressure by 1.48 mmHg when compared to control subjects (12 comparisons; -1.48 [-2.79 to -0.16] mmHg; P = 0.03). Subgroup analyses indicated larger reduction was identified in the intake of low-dose of grape polyphenols (

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0137665

DOI: 10.1371/journal.pone.0137665

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