Results of Vertebral Augmentation Treatment for Patients of Painful Osteoporotic Vertebral Compression Fractures: A Meta-Analysis of Eight Randomized Controlled Trials

Lianhua Li, Jixin Ren, Jia Liu, Hao Wang, Xiaowei Wang, Zhi Liu and Tiansheng Sun

PLOS ONE, 2015, vol. 10, issue 9, 1-11

Abstract: Background: In 2009 two RCTs were publicated to question the efficacy of vertebroplasty comparing with sham treatment (ST) in the New England Journal of Medicine (NEJM), which provoked an academic debate on the efficacy of PVA. The purposes of our study were to compare clinical differences in pain relief, spinal functional outcomes, and overall quality of life between PVA and CT for painful osteoporotic VCFs. Methods: We searched PubMed, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials and Web of Knowledge from January 1980 to June 2013 with Medical Subject Headings terms and keywords. Risk of bias in the included studies was assessed in accordance with the Cochrane risk of bias tool. In this Meta-analysis dichotomous and continuous variables were calculated using the risk ratio (RR) and standardized mean difference (SMD), respectively. Results: Eight studies involving 987 patients met the criteria for inclusion. The VAS SMD was favoring the experimental group significantly (p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0138126

DOI: 10.1371/journal.pone.0138126

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