Serum Sphingolipid Variations Associate with Hepatic Decompensation and Survival in Patients with Cirrhosis

Georgios Grammatikos, Nerea Ferreiròs, Oliver Waidmann, Dimitra Bon, Sirkka Schroeter, Alexander Koch, Eva Herrmann, Stefan Zeuzem, Bernd Kronenberger and Josef Pfeilschifter

PLOS ONE, 2015, vol. 10, issue 9, 1-15

Abstract: Background: Sphingolipids constitute bioactive molecules with functional implications in liver homeostasis. Particularly, ablation of very long chain ceramides in a knockout mouse model has been shown to cause a severe hepatopathy. Methods: We aimed to evaluate the serum sphingolipid profile of 244 patients with cirrhosis prospectively followed for a median period of 228±217 days via mass spectrometry. Results: We thereby observed a significant decrease of long and very long chain ceramides, particularly of C24ceramide, in patients with increasing severity of cirrhosis (p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0138130

DOI: 10.1371/journal.pone.0138130

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