Reproducibility of Volumetric Computed Tomography of Stable Small Pulmonary Nodules with Implications on Estimated Growth Rate and Optimal Scan Interval

Gary T Smith, Ahmad R Rahman, Ming Li, Brandon Moore, Hester Gietema, Giulia Veronesi, Pierre P Massion and Ronald C Walker

PLOS ONE, 2015, vol. 10, issue 9, 1-12

Abstract: Purpose: To use clinically measured reproducibility of volumetric CT (vCT) of lung nodules to estimate error in nodule growth rate in order to determine optimal scan interval for patient follow-up. Methods: We performed quantitative vCT on 89 stable non-calcified nodules and 49 calcified nodules measuring 3–13 mm diameter in 71 patients who underwent 3–9 repeat vCT studies for clinical evaluation of pulmonary nodules. Calculated volume standard deviation as a function of mean nodule volume was used to compute error in estimated growth rate. This error was then used to determine the optimal patient follow-up scan interval while fixing the false positive rate at 5%. Results: Linear regression of nodule volume standard deviation versus the mean nodule volume for stable non-calcified nodules yielded a slope of 0.057±0.002 (r2 = 0.79, p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0138144

DOI: 10.1371/journal.pone.0138144

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