Outcomes of Technical Variant Liver Transplantation versus Whole Liver Transplantation for Pediatric Patients: A Meta-Analysis

Hui Ye, Qiang Zhao, Yufang Wang, Dongping Wang, Zhouying Zheng, Paul Michael Schroder, Yao Lu, Yuan Kong, Wenhua Liang, Yushu Shang, Zhiyong Guo and Xiaoshun He

PLOS ONE, 2015, vol. 10, issue 9, 1-13

Abstract: Objective: To overcome the shortage of appropriate-sized whole liver grafts for children, technical variant liver transplantation has been practiced for decades. We perform a meta-analysis to compare the survival rates and incidence of surgical complications between pediatric whole liver transplantation and technical variant liver transplantation. Methods: To identify relevant studies up to January 2014, we searched PubMed/Medline, Embase, and Cochrane library databases. The primary outcomes measured were patient and graft survival rates, and the secondary outcomes were the incidence of surgical complications. The outcomes were pooled using a fixed-effects model or random-effects model. Results: The one-year, three-year, five-year patient survival rates and one-year, three-year graft survival rates were significantly higher in whole liver transplantation than technical variant liver transplantation (OR = 1.62, 1.90, 1.65, 1.78, and 1.62, respectively, p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0138202

DOI: 10.1371/journal.pone.0138202

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