Dietary Fat Intake and Risk of Gastric Cancer: A Meta-Analysis of Observational Studies

Jun Han, Yi Jiang, Xiao Liu, Qingyang Meng, Qiulei Xi, Qiulin Zhuang, Yusong Han, Ying Gao, Qiurong Ding and Guohao Wu

PLOS ONE, 2015, vol. 10, issue 9, 1-18

Abstract: Background and Objectives: Consumption of dietary fat has been reported to be associated with gastric cancer risk, but the results of epidemiologic studies remain inconsistent. We conducted a meta-analysis to summarize the evidence regarding the association between dietary fat intake and gastric cancer risk. Methods: A comprehensive search of PubMed and EMBASE was performed to identify observational studies providing quantitative estimates between dietary fat and gastric cancer risk. Random effects model was used to calculate the summary relative risk(SRR) in the highest versus lowest analysis. Categorical dose-response analysis was conducted to quantify the association between dietary fat intake and gastric cancer risk. Heterogeneity among studies was evaluated using I2 and tau2(between study variance)statistics. Subgroup analysis and publication bias analysis were also performed. Results: Twenty-two articles were included in the meta-analysis. The SRR for gastric cancer was 1.18 for individuals with highest intake versus lowest intake of total fat (95% confidence interval [CI]: 0.999–1.39; n = 28; P

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0138580

DOI: 10.1371/journal.pone.0138580

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