Efficacy of Procyanidins against In Vivo Cellular Oxidative Damage: A Systematic Review and Meta-Analysis

Shugang Li, Mengchuan Xu, Qiang Niu, Shangzhi Xu, Yusong Ding, Yizhong Yan, Shuxia Guo and Feng Li

PLOS ONE, 2015, vol. 10, issue 10, 1-14

Abstract: Aims: In this study, the efficacy of proanthocyanidins (PCs) against oxidative damage was systematically reviewed to facilitate their use in various applications. Methods: A meta-analysis was performed by two researchers. Each investigator independently searched electronic databases, including Cochrane, PubMed, Springer, Web of Science, China National Knowledge Infrastructure (CKNI), China Science and Technology Journal Database (CSTJ), and WanFang Data, and analyzed published data from 29 studies on the effects of PCs against oxidative damage. Oxidative stress indexes included superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), and total antioxidative capacity (T-AOC). Results: Compared with the oxidative damage model group, PCs effectively improved the T-AOC, SOD, GSH, GPx, and CAT levels, and reduced the MDA levels; these differences were statistically significant (P

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0139455

DOI: 10.1371/journal.pone.0139455

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