Serum IL-10 Predicts Worse Outcome in Cancer Patients: A Meta-Analysis

Shuai Zhao, Dang Wu, Pin Wu, Zhen Wang and Jian Huang

PLOS ONE, 2015, vol. 10, issue 10, 1-15

Abstract: Background: IL–10 is an important immunosuppressive cytokine which is frequently elevated in tumor microenvironment. Some studies have reported that overexpression of serous IL–10 is correlated with worse outcome in patients with malignant tumor. Here, we conducted a meta-analysis to assess the prognostic impact of serous IL–10 expression in cancer patients. Methods: We searched PubMed and EBSCO for studies in evaluating the association of IL–10 expression—in serum and clinical outcome in cancer patients. Overall survival (OS) was the primary prognostic indicator and disease-free survival (DFS) was the secondary indicator. Extracted data were computed into odds ratios (ORs) and 95% confidence interval (CI) or a P value for survival at 1, 3 and 5 years. Pooled data were weighted using the Mantel–Haenszel Fixed-effect model. All statistical tests were two-sided. Results: A total of 1788 patients with cancer from 21 published studies were incorporated into this meta-analysis. High level of serum IL–10 was significantly associated with worse OS at 1-year (OR = 3.70, 95% CI = 2.81 to 4.87, P

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0139598

DOI: 10.1371/journal.pone.0139598

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