Predicting Pathological Features at Radical Prostatectomy in Patients with Prostate Cancer Eligible for Active Surveillance by Multiparametric Magnetic Resonance Imaging

Ottavio de Cobelli, Daniela Terracciano, Elena Tagliabue, Sara Raimondi, Danilo Bottero, Antonio Cioffi, Barbara Jereczek-Fossa, Giuseppe Petralia, Giovanni Cordima, Gilberto Laurino Almeida, Giuseppe Lucarelli, Carlo Buonerba, Deliu Victor Matei, Giuseppe Renne, Giuseppe Di Lorenzo and Matteo Ferro

PLOS ONE, 2015, vol. 10, issue 10, 1-14

Abstract: Purpose: The aim of this study was to investigate the prognostic performance of multiparametric magnetic resonance imaging (mpMRI) and Prostate Imaging Reporting and Data System (PIRADS) score in predicting pathologic features in a cohort of patients eligible for active surveillance who underwent radical prostatectomy. Methods: A total of 223 patients who fulfilled the criteria for “Prostate Cancer Research International: Active Surveillance”, were included. Mp–1.5 Tesla MRI examination staging with endorectal coil was performed at least 6–8 weeks after TRUS-guided biopsy. In all patients, the likelihood of the presence of cancer was assigned using PIRADS score between 1 and 5. Outcomes of interest were: Gleason score upgrading, extra capsular extension (ECE), unfavorable prognosis (occurrence of both upgrading and ECE), large tumor volume (≥0.5ml), and seminal vesicle invasion (SVI). Receiver Operating Characteristic (ROC) curves and Decision Curve Analyses (DCA) were performed for models with and without inclusion of PIRADS score. Results: Multivariate analysis demonstrated the association of PIRADS score with upgrading (P

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0139696

DOI: 10.1371/journal.pone.0139696

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