Causes of Death among AIDS Patients after Introduction of Free Combination Antiretroviral Therapy (cART) in Three Chinese Provinces, 2010–2011

Liyan Wang, Lin Ge, Lu Wang, Jamie P Morano, Wei Guo, Kaveh Khoshnood, Qianqian Qin, Zhengwei Ding, Dingyong Sun, Xiaoyan Liu, Hongbing Luo, Jonas Tillman and Yan Cui

PLOS ONE, 2015, vol. 10, issue 10, 1-12

Abstract: Introduction: Although AIDS-related deaths have had significant economic and social impact following an increased disease burden internationally, few studies have evaluated the cause of AIDS-related deaths among patients with AIDS on combination anti-retroviral therapy (cART) in China. This study examines the causes of death among AIDS-patients in China and uses a methodology to increase data accuracy compared to the previous studies on AIDS-related mortality in China, that have taken the reported cause of death in the National HIV Registry at face-value. Methods: Death certificates/medical records were examined and a cross-sectional survey was conducted in three provinces to verify the causes of death among AIDS patients who died between January 1, 2010 and June 30, 2011. Chi-square analysis was conducted to examine the categorical variables by causes of death and by ART status. Univariate and multivariate logistic regression were used to evaluate factors associated with AIDS-related death versus non-AIDS related death. Results: This study used a sample of 1,109 subjects. The average age at death was 44.5 years. AIDS-related deaths were significantly higher than non-AIDS and injury-related deaths. In the sample, 41.9% (465/1109) were deceased within a year of HIV diagnosis and 52.7% (584/1109) of the deceased AIDS patients were not on cART. For AIDS-related deaths (n = 798), statistically significant factors included CD4 count

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0139998

DOI: 10.1371/journal.pone.0139998

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