Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRLlpr Mice

Bastian Schirmer, Dirk Wedekind, Silke Glage and Detlef Neumann

PLOS ONE, 2015, vol. 10, issue 10, 1-11

Abstract: The role of IL-18 in the pathogenesis of systemic lupus erythematosus is still not definitively solved. In this study, we generated MRLlpr mice, which develop a disease resembling systemic lupus erythematosus, genetically devoid of IL-18 expression. These mice in comparison to IL-18-competent MRLlpr mice show reduced signs of renal pathogenesis, while other parameters such as mean survival time, lymphadenopathy, constitutive interferon-γ production, and frequency of CD3+B220+ abnormal T cells were without differences. We conclude that in the systemic lupus erythematosus syndrom IL-18 is involved specifically in the renal pathogenesis.

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0140173

DOI: 10.1371/journal.pone.0140173

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