Standardised Resting Time Prior to Blood Sampling and Diurnal Variation Associated with Risk of Patient Misclassification: Results from Selected Biochemical Components

Ida B Andersen, Claus L Brasen, Henry Christensen, Lene Noehr-Jensen, Dorthe E Nielsen, Ivan Brandslund and Jonna S Madsen

PLOS ONE, 2015, vol. 10, issue 10, 1-9

Abstract: Background: According to current recommendations, blood samples should be taken in the morning after 15 minutes’ resting time. Some components exhibit diurnal variation and in response to pressures to expand opening hours and reduce waiting time, the aims of this study were to investigate the impact of resting time prior to blood sampling and diurnal variation on biochemical components, including albumin, thyrotropin (TSH), total calcium and sodium in plasma. Methods: All patients referred to an outpatient clinic for blood sampling were included in the period Nov 2011 until June 2014 (opening hours: 7am–3pm). Each patient’s arrival time and time of blood sampling were registered. The impact of resting time and the time of day for all components was analysed using simple linear regression. The “maximum allowable bias” was used as quality indicator for the change in reference interval. Results: Significant diurnal variation was found for albumin (n = 15,544; p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0140475

DOI: 10.1371/journal.pone.0140475

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