Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study

Tess V Clendenen, Wenzhen Ge, Karen L Koenig, Tomas Axelsson, Mengling Liu, Yelena Afanasyeva, Anne Andersson, Alan A Arslan, Yu Chen, Göran Hallmans, Per Lenner, Tomas Kirchhoff, Eva Lundin, Roy E Shore, Malin Sund and Anne Zeleniuch-Jacquotte

PLOS ONE, 2015, vol. 10, issue 10, 1-11

Abstract: Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies have examined SNPs in vitamin D-related genes other than the vitamin D receptor (VDR) gene and particularly have not examined the association with the retinoid X receptor alpha (RXRA) gene which may be a key vitamin D pathway gene. We conducted a nested case-control study of 734 cases and 1435 individually matched controls from a population-based prospective cohort study, the Northern Sweden Mammary Screening Cohort. Tag and functional SNPs were genotyped for the VDR, cytochrome p450 24A1 (CYP24A1), and RXRA genes. We also genotyped specific SNPs in four other genes related to vitamin D metabolism and signaling (GC/VDBP, CYP2R1, DHCR7, and CYP27B1). SNPs in the CYP2R1, DHCR7, and VDBP gene regions that were associated with circulating 25(OH)D concentration in GWAS were also associated with plasma 25(OH)D in our study (p-trend

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0140478

DOI: 10.1371/journal.pone.0140478

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