Serum Adiponectin and Glomerular Filtration Rate in Patients with Type 2 Diabetes

Lorena Ortega Moreno, Olga Lamacchia, Massimiliano Copetti, Lucia Salvemini, Concetta De Bonis, Salvatore De Cosmo, Mauro Cignarelli, Vincenzo Trischitta and Claudia Menzaghi

PLOS ONE, 2015, vol. 10, issue 10, 1-9

Abstract: High serum adiponectin has been increased in several conditions of kidney disease. Only sparse and conflicting results have been reported in patients with type 2 diabetes (T2D), a subgroup of individuals who are at high risk for renal dysfunction. The aim of this study was to fill up this gap of knowledge by investigating such association in a large sample of Italian diabetic patients. The association between serum adiponectin levels and estimated glomerular filtration rate (eGFR by Chronic Kidney Disease-Epidemiology Collaboration CKD-EPI equation) was investigated in 1,243 patients with T2D from two cross-sectional Italian studies: 878 from San Giovanni Rotondo (SGR) and 365 from Foggia (FG). Serum adiponectin was inversely associated with eGFR in SGR [β (standard error, SE) for 1 standard deviation (SD) of adiponectin = -3.26 (0.64)] and in FG [β(SE)=-5.70(1.28)] sample, as well as in the two studies combined [β(SE)=-3.99(0.59)];(p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0140631

DOI: 10.1371/journal.pone.0140631

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