Relationship between Blood Myostatin Levels and Kidney Function:Shimane CoHRE Study

Shozo Yano, Atsushi Nagai, Minoru Isomura, Masayuki Yamasaki, Tsunetaka Kijima, Miwako Takeda, Tsuyoshi Hamano and Toru Nabika

PLOS ONE, 2015, vol. 10, issue 10, 1-9

Abstract: Objectives: Myostatin (MSTN), a member of TGF-β superfamily, is produced in the skeletal muscle to inhibit myocyte differentiation. MSTN expression is increased in the skeletal muscle in patients with chronic kidney disease (CKD), which may play a role in the pathogenesis of sarcopenia or in the protein energy wasting (PEW). This observation implies that the plasma MSTN level may be correlated with kidney function. Thus, we conducted a cross-sectional study to evaluate the association between the plasma MSTN concentration and the estimated glomerular filtration rate (eGFR). Subjects and Methods: Subjects were 781 participants of a health examination performed in a rural area in Japan. Among them, 124 subjects were selected by stratified random sampling according to eGFR. Creatinine clearance (ClCr) by the Cockcroft-Gault equation was used as a measure of kidney function. Plasma concentration of MSTN was determined by ELISA. Results: The plasma MSTN level was not different between men (3.42±1.61 ng/mL) and women (3.27±1.43 ng/mL). In a simple regression analysis, the MSTN level was significantly correlated with eGFR (r = -0.25, p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0141035

DOI: 10.1371/journal.pone.0141035

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