Radical Prostatectomy versus External Beam Radiotherapy for cT1-4N0M0 Prostate Cancer: Comparison of Patient Outcomes Including Mortality

Satoru Taguchi, Hiroshi Fukuhara, Kenshiro Shiraishi, Keiichi Nakagawa, Teppei Morikawa, Shigenori Kakutani, Yuta Takeshima, Hideyo Miyazaki, Tetsuya Fujimura, Tohru Nakagawa, Haruki Kume and Yukio Homma

PLOS ONE, 2015, vol. 10, issue 10, 1-12

Abstract: Background: Although radical prostatectomy (RP) and external beam radiotherapy (EBRT) have been considered as comparable treatments for localized prostate cancer (PC), it is controversial which treatment is better. The present study aimed to compare outcomes, including mortality, of RP and EBRT for localized PC. Methods: We retrospectively analyzed 891 patients with cT1-4N0M0 PC who underwent either RP (n = 569) or EBRT (n = 322) with curative intent at our single institution between 2005 and 2012. Of the EBRT patients, 302 (93.8%) underwent intensity-modulated radiotherapy. Primary endpoints were overall survival (OS) and cancer-specific survival (CSS). Related to these, other-cause mortality (OCM) was also calculated. Biochemical recurrence-free survival was assessed as a secondary endpoint. Cox proportional hazards model was used for multivariate analysis. Results: Median follow-up durations were 53 and 45 months, and median ages were 66 and 70 years (P

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0141123

DOI: 10.1371/journal.pone.0141123

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