Genome-Wide Locations of Potential Epimutations Associated with Environmentally Induced Epigenetic Transgenerational Inheritance of Disease Using a Sequential Machine Learning Prediction Approach

M Muksitul Haque, Lawrence B Holder and Michael K Skinner

PLOS ONE, 2015, vol. 10, issue 11, 1-25

Abstract: Environmentally induced epigenetic transgenerational inheritance of disease and phenotypic variation involves germline transmitted epimutations. The primary epimutations identified involve altered differential DNA methylation regions (DMRs). Different environmental toxicants have been shown to promote exposure (i.e., toxicant) specific signatures of germline epimutations. Analysis of genomic features associated with these epimutations identified low-density CpG regions (

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0142274

DOI: 10.1371/journal.pone.0142274

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