Evolution of Costs of Inflammatory Bowel Disease over Two Years of Follow-Up

Mirthe E van der Valk, Marie-Josée J Mangen, Mirjam Severs, Mike van der Have, Gerard Dijkstra, Ad A van Bodegraven, Herma H Fidder, Dirk J de Jong, C Janneke van der Woude, Mariëlle J L Romberg-Camps, Cees H M Clemens, Jeroen M Jansen, Paul C van de Meeberg, Nofel Mahmmod, Andrea E van der Meulen-de Jong, Cyriel Y Ponsioen, Clemens Bolwerk, J Reinoud Vermeijden, Peter D Siersema, Max Leenders, Bas Oldenburg and COIN study group and the Dutch Initiative on Crohn and Colitis

PLOS ONE, 2016, vol. 11, issue 4, 1-11

Abstract: Background: With the increasing use of anti-TNF therapy in inflammatory bowel disease (IBD), a shift of costs has been observed with medication costs replacing hospitalization and surgery as major cost driver. We aimed to explore the evolution of IBD-related costs over two years of follow-up. Methods and Findings: In total 1,307 Crohn's disease (CD) patients and 915 ulcerative colitis (UC) patients were prospectively followed for two years by three-monthly web-based questionnaires. Changes of healthcare costs, productivity costs and out-of-pocket costs over time were assessed using mixed model analysis. Multivariable logistic regression analysis was used to identify costs drivers. In total 737 CD patients and 566 UC were included. Total costs were stable over two years of follow-up, with annual total costs of €7,835 in CD and €3,600 in UC. However, within healthcare costs, the proportion of anti-TNF therapy-related costs increased from 64% to 72% in CD (p

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0142481

DOI: 10.1371/journal.pone.0142481

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