Maternal Diabetes and Cognitive Performance in the Offspring: A Systematic Review and Meta-Analysis

Maria Camprubi Robles, Cristina Campoy, Llenalia Garcia Fernandez, Jose M Lopez-Pedrosa, Ricardo Rueda and Maria J Martin

PLOS ONE, 2015, vol. 10, issue 11, 1-16

Abstract: Objective: Diabetes during gestation is one of the most common pregnancy complications associated with adverse health effects for the mother and the child. Maternal diabetes has been proposed to negatively affect the cognitive abilities of the child, but experimental research assessing its impact is conflicting. The main aim of our study was to compare the cognitive function in children of diabetic and healthy pregnant women. Methods: A systematic review and meta-analysis was conducted through a literature search using different electronic databases from the index date to January 31, 2015. We included studies that assessed the cognitive abilities in children (up to 14 years) of diabetic and non-diabetic mothers using standardized and validated neuropsychological tests. Results: Of 7,698 references reviewed, 12 studies involving 6,140 infants met our inclusion criteria and contributed to meta-analysis. A random effect model was used to compute the standardized mean differences and 95% confidence interval (CI) were calculated. Infants (1–2 years) of diabetic mothers had significantly lower scores of mental and psychomotor development compared to control infants. The effect size for mental development was -0.41 (95% CI -0.59, -0.24; p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0142583

DOI: 10.1371/journal.pone.0142583

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