Role of Right Ventricular Global Longitudinal Strain in Predicting Early and Long-Term Mortality in Cardiac Resynchronization Therapy Patients

Vivien Klaudia Nagy, Gábor Széplaki, Astrid Apor, Valentina Kutyifa, Attila Kovács, Annamária Kosztin, Dávid Becker, András Mihály Boros, László Gellér and Béla Merkely

PLOS ONE, 2015, vol. 10, issue 12, 1-11

Abstract: Background: Right ventricular (RV) dysfunction has been associated with poor prognosis in chronic heart failure (HF). However, less data is available about the role of RV dysfunction in patients with cardiac resynchronization therapy (CRT). We aimed to investigate if RV dysfunction would predict outcome in CRT. Design: We enrolled prospectively ninety-three consecutive HF patients in this single center observational study. All patients underwent clinical evaluation and echocardiography before CRT and 6 months after implantation. We assessed RV geometry and function by using speckle tracking imaging and calculated strain parameters. We performed multivariable Cox regression models to test mortality at 6 months and at 24 months. Results: RV dysfunction, characterized by decreased RVGLS (RV global longitudinal strain) [10.2 (7.0–12.8) vs. 19.5 (15.0–23.9) %, p

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0143907

DOI: 10.1371/journal.pone.0143907

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