Association between Herpesviruses and Chronic Periodontitis: A Meta-Analysis Based on Case-Control Studies

Ce Zhu, Fei Li, May Chun Mei Wong, Xi-Ping Feng, Hai-Xia Lu and Wei Xu

PLOS ONE, 2015, vol. 10, issue 12, 1-13

Abstract: Objective: Numerous studies have investigated the associations between herpesviruses and chronic periodontitis; however, the results remain controversial. To derive a more precise estimation, a meta-analysis on all available studies was performed to identify the association between herpesviruses and chronic periodontitis. Methods: A computerized literature search was conducted in December 2014 to identify eligible case-control studies from the PUBMED and EMBASE databases according to inclusion and exclusion criteria. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were used to assess the association between herpesviruses and risk of chronic periodontitis. A fixed or random effects model was determined based on a heterogeneity test. Sensitivity analysis was conducted to investigate stability and reliability. Publication bias was investigated using the Begg rank correlation test and Egger's funnel plot. Results: Ten eligible studies were included to investigate the association between Epstein–Barr virus (EBV) and chronic periodontitis. The results showed that EBV has a significant association with chronic periodontitis compared with periodontally healthy group (OR = 5.74, 95% CI = 2.53–13.00, P

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0144319

DOI: 10.1371/journal.pone.0144319

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