Clinicopathological Characteristics and Survival Outcomes of Primary Signet Ring Cell Carcinoma in the Stomach: Retrospective Analysis of Single Center Database

Xiaowen Liu, Hong Cai, Weiqi Sheng, Lin Yu, Ziwen Long, Yingqiang Shi and Yanong Wang

PLOS ONE, 2015, vol. 10, issue 12, 1-13

Abstract: Purpose: To investigate the clinicopathological features and prognosis of signet ring cell carcinoma of the stomach (SRC). Methods: A total of 1464 gastric cancer patients who underwent curative gastrectomy from 2000 to 2008 at a single center were evaluated. Signet ring cell carcinoma (SRC) was defined as the presence of at least 50% signet ring cells in the pathologic specimen. The clinicopathological parameters and prognosis of SRC were analyzed by comparing with non-signet ring cell carcinoma (NSRC). Results: Of 1464 patients, 138 patients (9.4%) were classified as SRC. There were significant differences in gender, age, tumor location, TNM stage, p21 expression, and p53 expression between SRC and NSRC. The 5-year survival rates of SRC and NSRC were 36.2% and 49.5%, respectively. The prognosis of SRC was poorer than that of NSRC (P

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0144420

DOI: 10.1371/journal.pone.0144420

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