Prognostic Significance of Preoperative Albumin-Globulin Ratio in Patients with Upper Tract Urothelial Carcinoma

Bo Zhang, Wei Yu, Li-Qun Zhou, Zhi-Song He, Cheng Shen, Qun He, Jun Li, Li-Bo Liu, Cong Wang, Xiao-Yu Chen, Yu Fan, Shuai Hu, Lei Zhang, Wen-Ke Han and Jie Jin

PLOS ONE, 2015, vol. 10, issue 12, 1-12

Abstract: Background: Preoperative albumin-globulin ratio (AGR) reflects both malnutrition and systemic inflammation in cancer patients. In particular, systemic inflammation has been reported to contribute to tumor progression and poor oncological outcome in various malignancies. However, the prognostic value of preoperative AGR in upper tract urothelial carcinoma (UTUC) has not been examined. Methods: We retrospectively reviewed medical data of 187 operable UTUC patients in a Chinese cohort with a high incidence of chronic kidney disease (CKD). AGR was calculated as [AGR = albumin/(serum total protein—albumin)]. The associations of preoperative AGR with clinicopathologic characteristics and prognosis were assessed. Multivariate analyses using Cox regression models were performed to determine the independent prognostic factors. Results: The median (IQR) preoperative AGR was 1.50 (1.30–1.70), and the optimal cutoff value was determined to be 1.45 according to the receiver operating curve analysis. Low AGR was significantly associated with female gender, high CKD stage and tumor grade (P

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0144961

DOI: 10.1371/journal.pone.0144961

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